A new synthetic route of 5750-76-5

The chemical industry reduces the impact on the environment during synthesis 5750-76-5, I believe this compound will play a more active role in future production and life.

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5750-76-5 as follows., 5750-76-5

2,4,5-trichloropyrimidine (6.1 kg)To 2- (isopropylsulfonyl) aniline (950 g, 4.77 mol) and DBU (181 g, 1.19 mol, 0.25 equiv.)The mixture was stirred at 80 C. for 7.5 hours.After cooling to 25 C,n-heptane (1.9 kg) was added,The mixture was stirred for 30 minutes.Cool the mixture to -5 C.Filter and wash with n-heptane (325 g).The crude product is suspended in ethanol (4.5 kg),Stirred at 25 C. for 12 hours, then cooled to 0 C.After filtration, the crude was dried in vacuo,2,5-dichloro-N- (2- (isopropylsulfonyl) phenyl) pyrimidin-4-amine(1.07 kg, 65% yield).

The chemical industry reduces the impact on the environment during synthesis 5750-76-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Novartis AG; Kapferer, Tobias; Gong, Baoqing; Davis, Mark Clinton; Zheng, Xuchun; (72 pag.)JP2019/196359; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia