Related Products of 5767-35-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5767-35-1, name is 4-Chloro-6-hydrazinopyrimidine, molecular formula is C4H5ClN4, molecular weight is 144.56, as common compound, the synthetic route is as follows.
Intermediate-21 A (13.0mL, 69.2mmol) and 1N 26 HCl (10mL) were added dropwise in the solution of 27 C (10.0g, 69.2mmol) in 23 ethanol (100mL) at 0-5C and was stirred for 1h. Completion of reaction was confirmed on TLC after 1h. Then reaction mixture was poured on ice water to afford crude product. Filtration and recrystallization from ethanol of crude product yielded 28 ethyl 1-(6-chloropyrimidin-4-yl)-5-methyl-1H-pyrazole-4-carboxylate (B) as white crystals [47]. Yield 90%; Rf=0.8 (hexane:ethyl acetate, 4:1); m.p. 180C; 1H NMR 8.94 (s, 1H), 8.42 (s, 1H), 7.238 (s, 1H), 4.216 (q, J=7.2Hz, 2H), 2.782 (s, 3H), 1.312 (t, J=7.2Hz, 3H). EI-MS (m/z): 268.07 (M+2).
Statistics shows that 5767-35-1 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-6-hydrazinopyrimidine.
Reference:
Article; Vekariya, Mayur K.; Patel, Dhaval B.; Pandya, Pranav A.; Vekariya, Rajesh H.; Shah, Prapti U.; Rajani, Dhanji P.; Shah, Nisha K.; Journal of Molecular Structure; vol. 1175; (2019); p. 551 – 565;,
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