The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3435-28-7, name is 6-Methylpyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H7N3
A mixture of 3-[3,5-dichloro-4-(4-chlorothiazolo[5,4- c]pyridin-2-yl)-phenyl]-azetidine-l-carboxylic acid ferf-butyl ester (0.106 g, 0.225 mmol), 6- methylpyrimidin-4-ylamine (0.024 g, 0.248 mmol), XantPhos (0.013 g, 0.023 mmol), Pd2(dba)3 (0.010 g, 0.0113 mmol) and CS2CO3 (0.147 g, 0.45 mmol) in dioxane (2 mL) was degassed with a stream of argon. The reaction mixture was heated at 85 C for 18 hours. Additional Pdi(dba)3 (0.005 g), XantPhos (0.007 g) and 6- methylpyrimidin-4-ylamine (0.006 g) were added and the mixture was heated at 85 C for 18 hours. After cooling to room temperature, the crude reaction mixture was filtered through Celite and the filtrate was concentrated under reduced pressure. The resultant residue was purified by column chromatography on silica gel eluting with 0-90% EtOAc in petroleum ether to afford the title compound as a pale yellow glass (64 mg, 52% yield). NMR (400 MHz, CDC13): delta 8.71 (s, 1H), 8.45 (d, J = 5.7 Hz, 1H), 8.15 (s, 1H), 7.76 (d, J = 5.6 Hz, 1H), 7.51-7.41 (m, 3H), 4.39 (t, J = 8.7 Hz, 2H), 4.02-3.92 (m, 2H), 3.80-3.70 (m, 1H), 2.56 (s, 3H), 1.48 (s, 9H).
With the rapid development of chemical substances, we look forward to future research findings about 3435-28-7.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong; WO2012/35039; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia