Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60025-09-4, name is 4-Amino-6-chloropyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. 60025-09-4
4- Amino-6-(((lS, lR)-l-(3-(2-pyridinyl)-l,6-naphthyridin-2-yl)ethyl)amino)-5- pyrimidinecarbonitrile; To a stirred solution of l-(3-(pyridin-2-yl)-l,6-naphthyridin-2-yl)ethanamine (15 mg, 0.060 mmol) in butanol (1.5 mL) was added 4-amino-6-chloropyrimidine-5- carbonitrile (9.26 mg, 0.060 mmol) and N-ethyl-N-isopropylpropan-2-amine (20.9 uL, 0.120 mmol). The reaction was heated at 120 C for 2 h. After this time the reaction was cooled to r.t. The resulting precipitate was filtered and washed with hexanes to give racemic 4-amino-6-(((lS, lR)-l-(3-(2-pyridinyl)-l,6- naphthyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 9.33 (1 H, s), 8.83 (2 H, d, J=5.9 Hz), 8.33 (1 H, s), 8.14 (1 H, s), 8.02 (1 H, d, J=5.9 Hz), 7.93 (1 H, td, J=7.7, 1.8 Hz), 7.64 (2 H, d, J=7.8 Hz), 7.44 (1 H, ddd, J=7.6, 4.9, 1.0 Hz), 6.15 (1H, m), 5.28 (2 H, bs), 1.38 – 1.43 (3 H, m). Mass Spectrum (ESI) m/e = 251.0. Mass Spectrum (ESI) m/e = 369.2 (M+l).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,60025-09-4, 4-Amino-6-chloropyrimidine-5-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; AMGEN INC.; CHEN, Yi; CUSHING, Timothy, D.; FISHER, Benjamin; GONZALEZ LOPEZ DE TURISO, Felix; HAO, Xiaolin; SHIN, Youngsook; WO2012/87784; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia