Synthetic Route of 62802-42-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 62802-42-0 as follows.
2-Chloro-5-fluoropyrimidine (30g, 227mmol, 1 equiv), Zn(CN)2 (53g, 454mmol, 2 equiv), Pd(PPh3)4 (13. lg, l l .35mmol, 0.05 equiv) and DMF were charged into round bottom flask The mixture was degassed and refilled with N2 three times. Then the mixture was stirred at l30C overnight. The suspension was filtered. The filtrate was diluted with water and extracted with EtOAc three times. The organic layers were washed with brine, dried over anhydrous Na2S04, and filtered. The filtrate was adjusted to PH = 4 with 4 mol/L HCl/MeOH solution. Then the solution was concentrated to give crude 5- fluoropyrimidine-2-carbonitrile as brown oil which was used in next step without further purification. LC-MS: m/z 124.0 (M+H)+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62802-42-0, its application will become more common.
Reference:
Patent; ANNAPURNA BIO INC.; TANG, Haifeng; BOYCE, Sarah; HANSON, Michael; NIE, Zhe; (213 pag.)WO2019/169193; (2019); A1;,
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