Related Products of 6299-25-8 ,Some common heterocyclic compound, 6299-25-8, molecular formula is C5H4Cl2N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
4,6-dichloro-2-(methylthio)pyrimidine (0.7?g, 3.608?mmol) was dissolved in dichloromethane (15?mL), cooled to 0?C and meta-Chloroperoxybenzoic acid (m-CPBA) was added (1.55?g, 9.011?mmol) portion wise to the reaction mixture at the same temperature. After addition, the reaction mixture was allowed to stir for 4?h at room temperature. Then the reaction mass was quenched with an aqueous solution of sodium thiosulphate (11?mL) and extracted with dichloromethane (2?*?10?mL). Combined organic layer was washed with saturated aqueous NaHCO3 solution (15?mL), brine solution (7?mL), dried over anhydrous MgSO4, filtered and the filtrate was evaporated under reduced pressure to afford 4,6-dichloro-2-(methylsulfonyl)pyrimidine (0.65?g, 80.20%) as off-white solid ( Scheme -1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Murthy, P. Krishna; Valverde, Clodoaldo; Suneetha; Armakovi?, Stevan; Armakovi?, Sanja J.; Rani, N. Usha; Naidu, N. Venkatasubba; Journal of Molecular Structure; vol. 1186; (2019); p. 263 – 275;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia