In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 634-47-9 as follows. name: 2-Chloro-4-methylquinoline
The chloroquinoline (100 mg, 0.56 mmol) and piperidine (0.22 ml, 2.25 mmol) were stirred in a microwave reaction vial. The vial was sealed and then irradiated under microwave at 200 ¡ãC with stirring for 15 min. LC/MS indicated reaction completion. The reaction mixture was diluted with MeOH and then concentrated under vacuum. The residue was dissolved in 3percent aqueous HC1 (10 ml) and washed with dichloromethane (2 x 5 ml). The aqueous layer was treated with 2 N NaOH until the pH was 8, resulting in a white slurry. The slurry was extracted with dichloromethane (3 x 20 ml). The combined organic layers were dried over Na2SO4 and concentrated to give 70 mg (55percent) of the product as a white solid. 1H NMR (400 MHz, DMSO-d6): delta 7.75 (d, J = 8.1 Hz, 1H), 7.52-7.45 (m, 2H), 7.21-7.17 (m, 1H), 7.10 (s, 1H), 3.67 (bs, 4H), 2.54 (s, 3H), 1.62-1.55 (m, 6H). LC/MS: RT = 0.65 min, m/z = 227.2 [M + H]+.
According to the analysis of related databases, 634-47-9, the application of this compound in the production field has become more and more popular.