The chemical industry reduces the impact on the environment during synthesis 672-41-3, I believe this compound will play a more active role in future production and life.
In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 672-41-3 as follows., 672-41-3
Example 17N-{4-r(3-Methyl-4-oxo-3.4-dihvdroquinazolin-6-yl)oxylphenyl|-N’-r6- ftrifluoromethyl)pyrimidin-4-yl]urea; A the solution of 2,2,2-trichloro-N-{4-[(3-methyl-4-oxo-3,4-dihydroquinazolm-6- yl)oxy]phenyl}acetamide (Method 29, 206 mg, 0.50 mmol) andnuaOH (52 mg, 1.3 mmol) in DMSO (3 ml) was treated with 6-(trifluoromethyl)pyrimidin-4-amine (Method 30, 98 mg, 0.60 mmol). The reaction mixture was stirred at 80 C until the starting material was consumed. The reaction mixture was cooled to ~25 C and then added to water. The aqueous layer was extracted with DCM and the combined extracts were washed with NH4Cl(aq). The organic solution was dried over Na2SO4(S) and the solvents were removed under reduced pressure. The crude material was purified by crystallization to yield 80 mg of desired compound (35 %). NMR: 10.23 (s, 1 H), 9.67 (s, 1 H), 9.00 (s, 1 H), 8.31 (s, 1 H), 8.19 (s, 1 H), 7.71 (d, 1 H), 7.63 – 7.51 (m, 3 H), 7.46 – 7.39 (m, 1 H), 7.19 – 7.10 (m, 2 H), 3.46 (s, 3 H); m/z 456.
The chemical industry reduces the impact on the environment during synthesis 672-41-3, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/119055; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia