Synthetic Route of 1152475-42-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1152475-42-7, name is 7-Bromo-2-chlorothieno[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
Compound 1-h (671 mg, 1.64 mmol), 2-(methanesulfonyl)phenylboronic acid (328 mg, 1.64 mmol), bis(triphenylphosphine)palladium(II) dichloride (69 mg, 0.09 mmol) 2-di-tert-butylphosphino- 2?,4?,6?-triisopropylbiphenyl (63 mg,0.15 mmol) and 2 M aqueous sodium carbonate solution (6.5 mL, 13 mmol) were dissolved in 1,4-dioxane (13 mL). Thereaction mixture was replaced with nitrogen three times to remove the oxygen inside the system and then heated at90C for 6 hours. The reaction was cooled to room temperature, diluted with ice water (100 mL) and extracted withdichloromethane (100 mL 3 3). The combined organic phases were washed successively with water (50 mL 3 3) andbrine (50 mL),dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure.The residue was purified by silica gel thin layer chromatography preparative plate (dichloromethane: methanol = 40: 1)to deliver a yellow solid 5-b (130 mg, yield: 24%). LC-MS (ESI): m/z = 325 [M+H]+.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1152475-42-7, 7-Bromo-2-chlorothieno[3,2-d]pyrimidine.
Reference:
Patent; Guangzhou Maxinovel Pharmaceuticals Co., Ltd.; ZHANG, Nong; XU, Zusheng; WANG, Tinghan; WANG, Yuguang; (99 pag.)EP3287463; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia