A new synthetic route of 7-Bromo-4-chloropyrido[3,2-d]pyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,573675-31-7, its application will become more common.

Reference of 573675-31-7 ,Some common heterocyclic compound, 573675-31-7, molecular formula is C7H3BrClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1: 7-bromo-N-(2-methylbiphenyl-3-yl)pyrido[3,2-d]pyrimidin-4-amine To a vial was added 2-methylbiphenyl-3-amine (Example 1, Step 1: 0.4 g, 2.18 mmol), 7-bromo-4-chloropyrido[3,2-d]pyrimidine (Ark Pharm, cat#AK-27560: 540 mg, 2.2 mmol), and isopropyl alcohol (10. mL) The mixture was heated to 110 C. for 4 h. The mixture was cooled to room temperature, concentrated, and the crude product was used directly in the next step without further purification. LC-MS calculated for C20H16BrN4 (M+1)+: m/z=391.1; found 391.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,573675-31-7, its application will become more common.

Reference:
Patent; Incyte Corporation; Lajkiewicz, Neil; Wu, Liangxing; Yao, Wenqing; (58 pag.)US2017/174679; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia