Related Products of 24415-66-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 24415-66-5, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
Example 8: S-CCSR^RH-Methyl-S-CmethyKS-methyl-Il^^ltriazoloIl^-alphalpyrimidin-T- yl)amino)piperidin-l-yI)-3-oxopropanenitrile (56)To a solution of 7-chloro-5-methyl-[l,2,4]triazolo[l,5-a]pyrimidine (55) (0.145 g, 0.865 mmol) in dioxane (2 niL) was added 3-((3i?,4i?)-4-methyl-3-(methylamino)piperidin- 1 -yl)-3- oxopropanenitrile hydrochloride (21) (0.2 g, 0.86 mmol), potassium carbonate (0.119 g, 0.86 mmol), water (5 mL) and heated with stirring at 100 C for 4 h. The reaction mixture was diluted with water (10 mL) and extracted with ethyl acetate (2 x 100 mL). The organic layers were combined washed with water (20 mL), brine (10 mL), dried and concentrated in vacuum. The crude residue obtained was purified by flash column chromatography (silica gel 12 g, eluting with 0-50% CMA 80 in chloroform) to afford (56) which was re-crystallized from ethyl acetate to furnish 3- ((3i?,4i?)-4-Methyl-3-(methyl(5-methyl-[l,2,4]triazolo[l,5-alpha]pyrimidin-7-yl)amino)piperidin-l-yl)- 3-oxopropanenitrile (56) (18 mg, 6.35%) as a white solid; mp 119.3 0C. 1HNMR (300 MHz, DMSO) delta 8.37 (2s, IH), 6.43 (2s, IH), 5.26 – 5.04 (m, IH), 4.22 – 4.02 (m, 2H), 3.93 – 3.72 (m, 2H), 3.67 – 3.40 (m, IH), 3.30 – 3.14 (m, IH), 3.11 (2s, 3H), 2.47 (2s, 3H), 2.40 – 2.27 (m, IH), 1.79 – 1.48 (m, 2H), 1.05 (2d, J= 7.2, 3H); MS (ES+) 328.2 (100%: M+1); HPLC [(Zorbax SBC3, 3.0 x 150 mm, 5 mum, with a ZGC SBC3, 2.1 x 12.5 mm guard cartridge, “A” Buffer=(98% of 0.1 M Ammonium Acetate in 2% acetonitrile) “B” Buffer=100% Acetonitrile, UV Absorbance; Rt – 26.69, (99.51 %); Analysis: Calcd for C16H21N7O ? 0.25 H2O: C, 57.90; H, 6.52; N, 29.54; Found: C, 57.95; H, 6.48; N, 29.29.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 24415-66-5, 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine.
Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; CHAND, Pooran; KOTIAN, Pravin, L.; KUMAR, V., Satish; WO2010/14930; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia