75833-38-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 75833-38-4 as follows.
A mixture of 2-chloropyrimidine-4-carbonitrile (1 .5 g, 10.7 mmol), di-tert-butyldicarbonate (2.8 mL, 12.9 mmol) and 10% Pd/C (572 mg, 0.5 mmol) in EtOH(25 mL) was stirred at room temperature under a hydrogen atmosphere (1atm, balloon). After 4h, the reaction mixture was filtered through a pad ofCelite. The filtrate was concentrated under vacuum. Purification (FCC, 5i02, 0-99% EtOAc) to yield title product (720 mg, 27%). MS (ESI): mass calcd. forC10H14C1N302, 243.7; mlz found, 187.9 [M-t-Bu]. 1H NMR (400 MHz, DMSOd 5) O 8.72 (d, J= 5.1 Hz, 1H), 7.56 (t, J= 6.2 Hz, 1H), 7.39 (d, J= 5.1 Hz, 1H),4.21 (d, J = 6.0 Hz, 2H), 1.40 (5, 9H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75833-38-4, its application will become more common.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHEN, Gang; CHROVIAN, Christa C.; COATE, Heather R.; DVORAK, Curt A.; GELIN, Christine F.; HISCOX, Afton; LETAVIC, Michael A.; RECH, Jason C.; SOYODE-JOHNSON, Akinola; STENNE, Brice; WALL, Jessica L.; ZHANG, Wei; (583 pag.)WO2017/139428; (2017); A1;,
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