Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7752-78-5, name is 5-Bromo-2-methylpyrimidine. A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Bromo-2-methylpyrimidine
A mixture of [3-carbamoyl-5-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-indazol-l- yl]-acetic acid fert-butyl ester (200.0 mg , 0.498 mmol, 1.0 eq), 5-bromo-2-methyl-pyrimidine (103.5 mg, 0.6 mmol, 1.52 eq), Pd(PPh3)4 (29.0 mg, 0.025 mmol, 0.05 eq) and K2C03 (103.0 mg, 0.75 mmol, 1.5 eq) in 1,4- dioxane (10 mL) was stirred at 100 ¡ãC for 2 h. The mixture was concentrated and The resulting residue was purified by chromatography on silica gel column (PE/EA = 9/1, v/v) to give the fert-butyl 2-(3-carbamoyl-5- (2-methylpyrimidin-5-yl)-lH-indazol-l-yl)acetate (110 mg, 48percent). LRMS (M+H+) m/z calculated 368.16, found 368.1.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7752-78-5, 5-Bromo-2-methylpyrimidine.
Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (297 pag.)WO2018/229543; (2018); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia