7752-82-1, Adding a certain compound to certain chemical reactions, such as: 7752-82-1, 5-Bromopyrimidin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 7752-82-1, blongs to pyrimidines compound.
To a solution of 5-bromopyrimidin-2-amine (11, 5.22 g, 30 mmol) in DMF (50 mL) was added DMAP (366 mg, 3 mmol) and triethylamine (6.3 mL, 75 mmol), followed by the addition of di-tert-butyl dicarbonate (17 mL, 75 mmol). The reaction mixture was stirred at 60 C for 5 h, then the organic solvent was removed by rotary evaporation. MeOH (50 mL) and K2CO3 (2 equiv.) was added to the residue, then the mixture was stirred at 60 C for 1.5 h. The organic solvent was evaporated, and cold water was added. The formed precipitate was filtered off, washed with water, and dried to provide off-white solid 12 (7.38 g, 90% yield, Rf = 0.90 in CH2Cl2). 1H NMR (400 MHz, DMSO-d6) delta: 10.21 (s, 1H), 8.71 (s, 2H), 1.44 (s, 9H). 13C NMR (100 MHz, DMSO-d6) delta: 158.4, 156.5, 150.6, 112.3, 79.7, 27.9. MS (ESI + APCI) m/z: 274.0 [M-H]-, 276.0 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7752-82-1, its application will become more common.
Reference:
Article; Peng, Wei; Tu, Zheng-Chao; Long, Zi-Jie; Liu, Quentin; Lu, Gui; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 644 – 654;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia