Electric Literature of 779353-64-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 779353-64-9, name is 5,7-Dichloro-3-ethylpyrazolo[1,5-a]pyrimidine. A new synthetic method of this compound is introduced below.
Example 21. (S)-N-(4-( (3-ethyl-5-(2-(2-hydroxyethyl)piperidin-l-yl)pyrazolo[l, 5- a]pyrimidin-7-yl)amino)phenyl)acrylamide (MFH-1-187-1) teH-butyl4-(5-chloro-3-ethylpyrazolo[l,5-a]pyrimidin-7-ylamino)phenylcarbamate (MFH- 1-177-1) The mixture of SM-1-49-1 (500 mg, 2.314 mmol), SM-1-187-1 (520 mg, 2.5 mmol), DIPEA (898 mg) and i-PrOH (8 mL) was stirred at 85 C for 6 h. After completion, the solvent was removed and the residue was purified by silica gel chromatography (MeOH/DCM = 0-20%) to obtain MFH-1-177-1 (898 g, yield 100%). LCMS (m/z): 388 [M + H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,779353-64-9, 5,7-Dichloro-3-ethylpyrazolo[1,5-a]pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael, S.; ZHANG, Tinghu; KWIATKOWSKI, Nicholas, Paul; (299 pag.)WO2016/160617; (2016); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia