Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93366-88-2, name is 7H-Pyrrolo[2,3-d]pyrimidin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 93366-88-2
2 ‘ ,3 ‘ -Dideoxy-2 ‘ -fluoro-5 ‘ -O-tert-butyldimethylsilyl-4-chloro-7-deazaguanosine 18 A mixture of l-Chloro-2,3-dideoxy-2-fluoro-5-tert-butyldimethylsilylribose 17(880 mg, 2.24 mmol), 7-deazaguanidine (755 mg, 4.48 mmol), and powdered potassium hydroxide (377 mg, 6.72 mmol) in anhydrous acetonitrile (15 mL) was treated with catalytic amount of tris(2-(2- methoxyethoxy)ethyl) amine (72 mg, 0.224 mmol). After 12 h at rt, the mixture was concentrated and the resulting residue partitioned between ethyl acetate (100 mL) and water (50 mL). The aqueous phase was back extracted with ethyl acetate (2 x 25 mL) and the combined organic phases dried over sodium sulfate, filtered and concentrated to dryness. The crude material was purified by flash column chromatography (25 mm x 170 mm) over silica gel using 9: 1 hexanes: ethyl acetate to give 18 (540 mg, 46%) as a white foam. 1H NMR (400 MHz, Chloroform-;/) delta 7.70 – 7.60 (m, 3H), 7.48 – 7.30 (m, 8H), 6.33 (d, J = 18.1 Hz, 1H), 6.25 (d, J = 3.8 Hz, 1H), 5.29 (dd, J = 51.9, 4.3 Hz, 1H), 4.96 (s, 2H), 4.48 (ddt, J = 11.1, 5.5, 3.1 Hz, 1H), 4.07 (dd, J = 11.8 Hz, 3.0 Hz, 1H), 3.76 (dd, J = 11.8, 3.3 Hz, 1H), 2.57 – 2.37 (m, 1H), 2.20 (ddd, J= 19.8, 14.3, 5.2 Hz, 1H), 1.07 (s, 9H).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 93366-88-2, 7H-Pyrrolo[2,3-d]pyrimidin-2-amine.
Reference:
Patent; EMORY UNIVERSITY; LIOTTA, Dennis, C.; PAINTER, George, R.; BLUEMLING, Gregory, R.; WO2014/124430; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia