With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.830346-47-9, name is 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C13H10F4N2O2, molecular weight is 302.22, as common compound, the synthetic route is as follows.Safety of 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione
To a 50 mL round botom flask was added AcOH (20 mL), compound IX (2 g) and N-Iodosuccinimide (1.5 g). The reaction mixture was heated to 50 °C for lh. After completion of the reaction, LLO (10 mL) was added to the reaction mixture. The resulting suspension was filtered. The cake was washed with MeOH (4 mL). The solid was slurried with MeOH (20 mL) to give the product as a white solid (2.3 g, 82percent yield, 96.1percent purity). NMR (400 MHz, DMSO-d6) d 11.75 (s, 1H), 77.67-7.61 (m, 1H), 7.59-7.50 (m, 2H), 5.39 (s, 1H), 2.56 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,830346-47-9, 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.
Reference:
Patent; WANG, Peng; LI, Pixu; GU, Xiangyong; YANG, Hailong; WANG, Zhong; JIANG, Qianghua; LIU, Yuanhua; XIA, Hui; (24 pag.)WO2019/112968; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia