A new synthetic route of 84905-80-6

The synthetic route of 84905-80-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 84905-80-6 , The common heterocyclic compound, 84905-80-6, name is 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 1-chloroisoquinoline 1a (2g, 12.225 mmol) in ethanol was added 4-fluorobenzenethiol 2a (1.436 mL, 13.447 mmol). The reaction was stirred at roomtemperature for 16h. The mixture was concentrated in vacuo. The crude waspurified by silica gel column chromatography using ethyl acetate/hexane to yieldpure compound (686 mg, 22%);

The synthetic route of 84905-80-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ahn, Jin Hee; Ahn, Se Hwan; Bae, Eun Jung; Bae, Myung Ae; Choi, Byeong Wook; Hwang, Kyu-Seok; Kim, Seong Soon; Lee, Byung Hoi; Shin, Dae-Seop; Yang, Jung Yoon; Bioorganic and medicinal chemistry letters; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia