In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 852180-74-6, name is 3-(Pyrimidin-5-yl)benzoic acid, the common compound, a new synthetic route is introduced below. Safety of 3-(Pyrimidin-5-yl)benzoic acid
To a stirred solution of XVII (0.100 g, 0.50 mmol) in 5 mL of DMF were added DIPEA (0.17 mL,1.0 mmol), HATU (0.380 g, 1.0 mmol) and XIII (0.203 g, 0.50 mmol) and stirred at RT for 12 h. Reactionmixture was diluted with ice-cold water and extracted with ethyl acetate (20 mL x 3). Organic layer wasthen washed with brine solution, dried over anhydrous sodium sulphate, concentrated under reducedpressure to afford crude product which was purified by reverse phase HPLC to afford desired product (0.053g, 18%).LCMS: 589 [M+1]+1H NMR (DMSO-d6): 10.50 (s, 1H), 10.20 (s, 1H), 9.25 (m, 3H), 8.43 (s, 1H), 8.20 (s, 1H), 8.10-8.05(m, 2H), 8.0 (m, 2H), 7.85 (d, 1H), 7.70 (m, 2H), 7.50 (d, 1H), 3.58 (s, 2H), 2.40-2.20 (m, 11H), 2.18 (s,3H).
The synthetic route of 852180-74-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
Pyrimidine | C4H4N2 – PubChem,
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