Adding a certain compound to certain chemical reactions, such as: 89167-24-8, 6-Bromo-[1,2,4]triazolo[1,5-a]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 89167-24-8, blongs to pyrimidines compound. COA of Formula: C5H3BrN4
2-(ri,2,41Triazolori,5-a1pyrazin-6-yl)-2,8-diazaspiror4.51decan-3-one : fert-Butvl 3-oxo-2,8- diazaspiro[4.5]decane-8-carboxylate (INTERMEDIATE 15) (50 mg, 0.197 mmol), 6- bromo[l,2,4]triazolo[l,5-a]pyrazine (58.8 mg, 0.296 mmol), copper(I) iodide (37.4 mg, 0.194 mmol), N,N’-dimethylethyldiamine (34.7 mg, 0.393 mmol) and cesium carbonate (192 mg, 0.59 mmol) were mixed in a 8 mL vial. 1,4-dioxanes (1ml) was added. The vial was then capped and the mixture was heated at 98C overnight. The reaction mixture was cooled to room temperature, water (1 mL) and ethyl acetate (3 mL) were added. The organic layer was then collected. Removal of solvent gave the crude product, to which was added HC1 in 1,4-dioxane (4M, lmL). The mixture was stirred at room temperature overnight. The solvent was then removed in vacuo to give the crude 2-([l,2,4]triazolo[l,5-a]pyrazin-6-yl)-2,8-diazaspiro[4.5]decan-3-one which was used without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89167-24-8, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; PIO, Barbara; CHOBANIAN, Harry, R.; SHI, Zhi-Cai; DONG, Shuzhi; GUO, Yan; WALSH, Shawn, P.; GUO, Zhiqiang; FERGUSON, Ronald, D.; CATO, Brian; (114 pag.)WO2016/60941; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia