Reference of 934524-10-4, Adding some certain compound to certain chemical reactions, such as: 934524-10-4, name is 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine,molecular formula is C13H9Cl2N3O2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 934524-10-4.
To a stirred solution of 4-methoxyphenol (87 mg, 0.70 mmol) in DMF (10 mL) was added Cs2CO3 (229 mg, 0.70 mmol). After 10 min, 2,4-dichloro-N-tosylpyrrolopyrimidine 3 (200 mg, 0.58 mmol) was added and the mixture was stirred at room temperature for 30 min. The reaction mixture was diluted with H2O (40 mL) and extracted with EtOAc (2 * 30 mL). The combined organic extracts were washed with brine (6 * 25 mL), dried, filtered and the solvent was removed in vacuo to give a grey residue. The residue was purified by flash chromatography (20% EtOAc/Hexanes) and recrystallised from n-PrOH to give 5c (150 mg, 51%) as a white solid; mp 161-164 C; deltaH (CDCl3): 8.10 (2H, d, J 8.0 Hz), 7.55 (1H, d, J 4.0 Hz), 7.32 (2H, d, J 8.0 Hz), 7.06 (2H, d, J 9.0 Hz), 6.90 (2H, d, J 9.0 Hz), 6.41 (1H, d, J 4.0 Hz), 3.81 (3H, s), 2.40 (3H, s); deltaC (CDCl3): 163.0, 157.5, 154.1, 153.2, 146.2, 145.5, 134.3, 129.9, 128.7, 124.9, 122.2, 114.7, 106.6, 102.3, 55.6, 21.7; m/z (ESI): 430.0 (M[35Cl]H+), 432.0 (M[37Cl]H+); HRMS (ESI): M[35Cl]H+, found 430.0636. C20H17ClN3O4S+ requires 430.0623.
According to the analysis of related databases, 934524-10-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; O’Brien, Nathan J.; Brzozowski, Martin; Buskes, Melissa J.; Deady, Leslie W.; Abbott, Belinda M.; Bioorganic and Medicinal Chemistry; vol. 22; 15; (2014); p. 3879 – 3886;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia