Adding a certain compound to certain chemical reactions, such as: 947533-45-1, 2-bromo-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 947533-45-1, blongs to pyrimidines compound. COA of Formula: C4H2BrFN2
A solution of NiCl2(glyme) (0.084 g, 0.384 mmol), 4-ie/7-butyl-2-(4-ie/7-butyl-2-pyridyl)pyridine, and Ir{dF(CF3)ppy}2(dtbpy)PF6(0.086 g, 0.077 mmol) in DME (80 mL) was sparged with N2for 15 min. The nickel solution was added to a mixture of //77-butyl 3- (bromomethyl)pyrrolidine-l-carboxylate (2.03 g, 7.68 mmol), 2-bromo-5-fluoro-pyrimidine (1.70 g, 9.61 mmol), tris(trimethylsilyl) silane (2.87 g, 11.5 mmol, 3.54 mL), and lithium hydroxide (0.736 mg, 30.7 mmol). After the mixture was sparged with N2(15 min), the reaction was irradiated with blue LEDs (48 watts 450 hv) overnight at 40 C. Celite was added to the reaction, and the mixture was filtered and concentrated in vacuo. The residue was purified over Si02(0-100% EtOAc:heptane) to afford the title compound (0.760 g). LCMS (ESI): [M – i-Bu] 226. 1HNMR: (500 MHz, CDCl3) d 8.39 (br d, 7=9.46 Hz, 2 H), 3.30 – 3.46 (m, 2 H), 3.10 – 3.21 (m, 1 H), 2.85 – 2.96 (m, 3 H), 2.54 – 2.66 (m, 1 H), 1.80 – 1.91 (m, 1 H), 1.42 – 1.57 (m, 1 H), 1.27 – 1.35 (m, 9 H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,947533-45-1, its application will become more common.
Reference:
Patent; BIOGEN MA INC.; GENUNG, Nathan; GUCKIAN, Kevin, M.; VESSELS, Jeffrey; ZHANG, Lei; GIANATASSIO, Ryan; LIN, Eaward Yin, Shiang; XIN, Zhili; (136 pag.)WO2019/178191; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia