Adding a certain compound to certain chemical reactions, such as: 99420-75-4, 5-Methylpyrimidine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines
To a solution of 5-methylpyrimidine-2-carboxylic acid (1 g, 7.24 mmol) in DMF(72.4 mL) was added 5-methylpyrimidine-2-carboxylic acid (1 g, 7.24mmol), and N,Odimethylhydroxylaminehydrochloride (0.777 g, 7.96 mmol). The mixture was cooled to0 C and 1-propanephosphonic acid cyclic anhydride, 50 wt.% solution in EtOAc (9.21mL, 14.48 mmol) was added dropwise. The mixture was allowed to warm toRTovernight. LCMS indicated complete conversion to product. The mixture was dilutedwith water, extracted with CHCb:IPA (3:1) and washed with brine and NaHC03. Themixture was then dried over Na2S04, concentrated in vacuo and purified by silica gelchromatography (0-100% heptanes:EtOAc) to yield Example 209.11 (0.7 g, 3.86 mmol,53.4% yield). 1H NMR (500 MHz, CDCb) o 8.61- 8.69 (m, 2 H) 3.61 -3.79 (m, 3 H)3.27- 3.47 (m, 3 H) 2.34- 2.45 (m, 3 H). LCMS-ESI (pos) m/z: 182.2 (M+Ht.
The synthetic route of 99420-75-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; CHEN, Yinhong; DRANSFIELD, Paul John; HARVEY, James S.; HEATH, Julie Anne; HOUZE, Jonathan; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; NISHIMURA, Nobuko; PATTAROPONG, Vatee; SWAMINATH, Gayathri; YEH, Wen-Chen; RAMSDEN, Philip Dean; (434 pag.)WO2018/93577; (2018); A1;,
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