Application of 372118-67-7 ,Some common heterocyclic compound, 372118-67-7, molecular formula is C5H8ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Tosyl chloride (254 mg, 1.33 mmol), K2CO3 (538 mg, 3.9 mmol) and compound 21 (500 mg, 1.33 mmol) were added to acetonitrile (10 mL) and stirred at room temperature overnight. Compound 23 (194 mg, 1.33 mmol) was added to the prepared mixed anhydride solution, stirred at room temperature for 20 minutes, and then detected by TLC. The reaction of the starting material was completed. The mixture was diluted with water and washed with ethyl acetate. The aqueous phase was extracted twice more with ethyl acetate. The combined organic phases were dried over anhydrous sodium sulfate and concentrated to give compound 24 (601 mg, 95% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,372118-67-7, its application will become more common.
Reference:
Patent; Anrun Pharmaceutical (Suzhou) Co., Ltd.; Hong Jian; Xu Xin; Liu Guobin; Liu Huahui; (14 pag.)CN104710411; (2017); B;,
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