Synthetic Route of 799842-07-2 , The common heterocyclic compound, 799842-07-2, name is N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide, molecular formula is C16H19BrFN3O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example-3Preparation of N-[4-(4-FIuoro-phenyl)-6-isopropyI-5-(pyridin-2-ylsulfanylmethyl)- pyrimidin-2-yI]-N-methyl-methanesulfonamide (III)2-mercaptopyridine (II) 3.23g was taken in 16mL tetrahydrofuran and chilled to -25 to -30 C and added 30% n-butyl lithium(l 1.OmL) drop wise at -5 to -10 C and stirred at the same temperature for one hour. Added N-[5-Bromomethyl-4-(4-fluoro-phenyl)-6- isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide (11. Og) dissolved in 22 mL THF at -60 C to -700C drop wise and stirred for 15 minutes at -60 to-70 C. Slowly brought the temperature to 250C and stirred for 2 h. Adjusted the pH of the reaction mixture to 7-8 with saturated ammonium chloride and added 5OmL ethyl acetate and separated the layers. Organic layer was given water washes and a brine wash. Organic layer was dried over anhydrous sodium sulphate and concentrated to get solid N-[4-(4- Fluoro-phenyl)-6-isopropyl-5-(pyridin-2-ylsulfanylmethyl)-pyrimidin-2-yl]-N-methyl- methanesulfonamide (V) Yield: 11. Og
The synthetic route of 799842-07-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOCON LIMITED; ANEGONDI, Sreenivasa, Prasad; RAJMAHENDRA, Shanmughasamy; JOSEPH, Jibin; SRINIVAS, Pullela, Venkata; WO2010/23678; (2010); A1;,
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