Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 26456-59-7, name is Pyrimidin-5-ol. A new synthetic method of this compound is introduced below., Recommanded Product: Pyrimidin-5-ol
To a solution of 5-hydroxypyrimidine (9, 1.73 kg, 18.08 mol) in DMF (23.0 L,10 V), potassium carbonate (6.25 kg, 45.21 mol) was added followed by 4-chloro-6-methylpicolinonitrile (8, 2.3 kg, 15.07 mol) at 25-30 C. The reactionmass was heated at 75-80 C for 36 h. The reaction was monitored by HPLC 8NMT 2.0% by HPLC). Reaction mass was cooled to 25-30 C. The solid wasfiltered and washed the solid with DMF (4.6 L, 2.0 V). The filtrate was cooled to0-5 C and purified water (27.6 L, 12 V) was added drop wise over a period of1 h. The solid precipitated was filtered and washed with purified water (2.3 L,10 V) to afford 10 as off white solid (2.62 kg, 82.1%). 1H NMR (400 MHz, DMSOd6)d 9.17 (s, 1H), 8.85 (s, 2H), 7.74 (d, J = 2.4 Hz, 1H), 7.32 (d, J = 2.3 Hz, 1H),2.48 (s, 3H); 13C NMR (100 MHz, DMSO-d6) d = 164.04, 162.28, 155.51, 150.02,148.75, 133.54, 117.05, 115.59, 115.04, 23.82 ppm; LCMS (Method 1):RT = 0.535 min, m/z = 213.2 [M+H]+; HRMS, calc?d for C11H8N4O [M],212.0698; found 212.0697.
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Reference:
Article; David, Thomas K.; Prashanth, Nayak K.; Rajendraswami; Pallalu, Devendrareddy; Castelhano, Arlindo L.; Kates, Michael J.; Blobaum, Anna L.; Jones, Carrie K.; Emmitte, Kyle A.; Conn, P. Jeffrey; Lindsley, Craig W.; Tetrahedron Letters; vol. 58; 36; (2017); p. 3554 – 3558;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia