Synthetic Route of 739364-95-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 739364-95-5, name is 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid. A new synthetic method of this compound is introduced below.
(Intermediate Example 113) 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (4-amino-4-methylpentyl)amide 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (177 mg) was suspended in tetrahydrofuran (5 ml), and N,N-dimethylformamide (1 drop) was added thereto. Oxalyl chloride (100 mul) was added thereto with ice cooling, and the mixture was stirred for 30 minutes at room temperature. The mixture was cooled again on ice, and 4-methyl-1,4-pentane< >diamine (116 mul) and triethylamine (0.21 ml) were added thereto and stirred overnight at room temperature. By adding water and 2 N hydrochloric acid, the reaction mixture was acidified, followed by washing with chloroform. The aqueous phase was alkalinized by 5 N sodium hydroxide solution, extracted with chloroform, and the extract was dried over sodium sulfate anhydrous. The product was concentrated under reduced pressure to give the title compound (151 mg, Y.: 55%) as pale yellow crystals. 1H NMR; (CDCl3) delta (ppm): 1.1 (6H, s), 1.7 (4H, m), 2.5 (3H, s), 3.4 (2H, dd), 6.5 (1H, s), 8.4 (1H, brs), 8.7 (1H, d), 9.1 (1H, d). ESI/MS (m/z): 276 (M+H)+, 274 (M-H)-.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,739364-95-5, its application will become more common.
Reference:
Patent; SANWA KAGAKU KENKYUSHO CO., LTD.; EP1595866; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia