Akbarzadeh, Marzieh; Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali; Azizollahi, Hamid; Mague, Joel T. published an article in 2018, the title of the article was Synthesis of 2-substituted-4-methyl-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-b]quinoxaline as a new heterocyclic system.Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:
2-Substituted-4-methyl-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-b]quinoxalines, e.g., I, were synthesized through cyclocondensation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with 3-aminoquinoxaline-2-thiol and subsequent substitution by various secondary amines. Regioselective heterocyclization was confirmed by X-ray crystallog. anal. for 4-methyl-2-(pyrrolidin-1-yl)-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-b]quinoxaline (I). The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione
The Article related to chloropyrimidinylmethylthio quinoxalinamine heterocyclization, chloropyrimidothiazepinoquinoxaline preparation secondary amine amination, aminopyrimidothiazepinequinoxaline preparation and other aspects.Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia