Theoretical and 15N NMR study of 6-amino-4-oxopyrimidines was written by Alderete, Joel B.;Madariaga, Sandra T.;Quiroga Y., Jairo;Insuasty, Braulio. And the article was included in Boletin de la Sociedad Chilena de Quimica in 1996.Formula: C6H9N3OS This article mentions the following:
We have carried out a theor. study, using semi-empirical methods, on the tautomerism of 2-methylthio-6-amino-4-oxopyrimidine (S6AMP) and 2-methoxy-6-amino-4-oxopyrimidine (O6AMP), bot in the gas phase and aqueous solution The results shows that in the gas phase and solution the oxoamino tautomer is the most stable in both compounds These compounds and N-Me derivatives were characterized by 15N-NMR. The spectra of S6AMP and O6AMP in trifluoroacetic acid indicate that the N1 of pyrimidine ring is the preferential site of protonation. This result is in keeping with the values of proton affinities, calculated by AM1 method. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Formula: C6H9N3OS).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Formula: C6H9N3OS
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia