Amano, Yohei; Noguchi, Masayuki; Shudo, Koichi published the artcile< Diarylamines incorporating hexahydrophenalene or octahydrobenzoheptalene as retinoid X receptor (RXR)-specific agonists>, Safety of Ethyl 2-chloropyrimidine-5-carboxylate, the main research area is arylamino hexahydro phenalene preparation retinoid X receptor agonist; octahydro benzoheptalene arylamino preparation retinoid X receptor agonist.
A series of diarylamines I (X = CH2, R1 = H, Me; X = CH2CH2, R1 = H; Z = CH, N; R2 = H, Me, Et, cyclopropylmethyl, i-Bu, PhCH2) incorporating hexahydrophenalene or octahydrobenzoheptalene as a hydrophobic moiety was synthesized and examined for their activities towards retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Most of these compounds showed agonistic activity towards RXRs, but were inactive towards RARs. These RXR-specific ligands showed synergistic activity in RARα,β ligand-induced terminal differentiation of leukemia cell line HL-60.
Chemical & Pharmaceutical Bulletin published new progress about Aromatic amines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 89793-12-4 belongs to class pyrimidines, and the molecular formula is C7H7ClN2O2, Safety of Ethyl 2-chloropyrimidine-5-carboxylate.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia