Application of 147539-23-9, Adding some certain compound to certain chemical reactions, such as: 147539-23-9, name is 1-Boc-4-(6-Chloro-5-nitro-4-pyrimidinyl)piperazine,molecular formula is C13H18ClN5O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 147539-23-9.
Example 84; 7-(2-Butynyl)-9-methyl-6-(piperazin-1-yl)-7,9-dihydropurin-8-thione trifluoroacetic acid salt; 84a) 4-(5-Amino-6-methylamino-pyrimidin-4-yl)piperazine-1-carboxylic acid t-butyl ester; [] 4-(6-Chloro-5-nitro-pyrimidin-4-yl)piperazine-1-carboxylic acid t-butyl ester (compound 61a) (5.0 g) was dissolved in acetonitrile (50 mL), and then methylamine (40%, methanol solution) (2.83 mL) was added to this solution. After stirring this reaction solution at room temperature for 17 hours, water (150 mL) was added. The reaction solution was stirred at room temperature for one hour, and then the precipitate was collected by filtration. The obtained yellow solid was washed with water and hexane to give a yellow solid (4.05 g). 1 g of the obtained yellow solid was dissolved in ethanol (20 mL). 10% palladium on carbon powder (wet) (200 mg) was then added to this solution. The reaction solution was stirred at room temperature for 15 hours under a hydrogen atmosphere. The insoluble substances were removed by filtration, and the obtained filtrate was concentrated under reduced pressure to give the title compound (920 mg).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 147539-23-9, 1-Boc-4-(6-Chloro-5-nitro-4-pyrimidinyl)piperazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Eisai Co., Ltd.; EP1568699; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia