109-12-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 109-12-6, name is Pyrimidin-2-amine. A new synthetic method of this compound is introduced below.
General procedure: To a solution of theappropriate amine (31-44, 10 mmol) and triethylamine (10 mmol) in anhydrous chloroform was added dropwisechloroacetylcloride (30, 12 mmol) at0-5 C and the mixture was stirred for 12 h at the same temperature under N2.Then the solvent was removed under vacuum, and the residue dissolved in ethylacetate was once washed with water. The organic phase was stirred with 10%activated charcoal for 30 min and filtered through a neutral alumina bed.Finally, the solvent was distilled under vacuum. It is worth mentioning thatall the products obtained decompose rapidly, therefore they were used immediatelyin the next reaction.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-12-6, Pyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Velazquez-Lopez, Jose Miguel; Hernandez-Campos, Alicia; Yepez-Mulia, Lilian; Tellez-Valencia, Alfredo; Flores-Carrillo, Paulina; Nieto-Meneses, Rocio; Castillo, Rafael; Bioorganic and Medicinal Chemistry Letters; vol. 26; 17; (2016); p. 4377 – 4381;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia