In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63206-77-9, name is [1,2,4]Triazolo[4,3-a]pyrimidin-3(2H)-one, the common compound, a new synthetic route is introduced below. Computed Properties of C5H4N4O
A mixture of 2H,3H-[1,2,4]triazolo[4,3-a]pyrimidin-3-one (20 mg, 0.15 mmol) (Intermediate 22) , 2-bromo-N-[(1S)-1-(4-chloro-3- fluorophenyl)ethyl]acetamide (43 mg, 0.15 mmol) (Intermediate 3) and potassium carbonate (61 mg, 0.44 mmol) in acetonitrile (2 mL) was heated to 60 C for 3 hours. The reaction was cooled and quenched into water. The aqueous layer was extracted into ethyl acetate three times, the combined organics were washed with brine, dried over MgSO4 and concentrated in vacuo. The residue was triturated with ethyl acetate and the solid material dried in vacuo to yield the title compound (22 mg, 43% yield).1H NMR (500 MHz, DMSO-d6) d 8.62 (d, J = 7.7 Hz, 1H), 8.55 (dd, J = 2.0, 3.8 Hz, 1H), 8.37 (dd, J = 2.0, 7.0 Hz, 1H), 7.54 (t, J = 8.1 Hz, 1H), 7.36 (dd, J = 1.9, 10.7 Hz, 1H), 7.20 (dd, J = 1.9, 8.3 Hz, 1H), 6.73 (dd, J = 3.8, 7.0 Hz, 1H), 4.94 (p, J = 7.0 Hz, 1H), 4.64 (d, J = 16.6 Hz, 1H), 4.59 (d, J = 16.6 Hz, 1H), 1.37 (d, J = 7.0 Hz, 3H). LCMS (Analytical Method A) Rt = 2.31min, MS (ESIpos): m/z= 350 [M+H]+, Purity = 98%.
The synthetic route of 63206-77-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BLACKTHORN THERAPEUTICS, INC.; JONES, Robert M.; BRANDT, Gary; (506 pag.)WO2020/97609; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
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