Application of 769-42-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 769-42-6, name is 1,3-Dimethylbarbituric acid, molecular formula is C6H8N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1,3-dimethylbarbituric acid (compound SM1) (7 kg, 44.9mmo1) dissolved in 120 kg phosphorus oxychloride (POCl3). To it, slowly drop water (2.2 kg, 22mo1). After dropping. slowly heating to reflux 6 hours; HPLC monitoring, after the reaction, the temperature, the reaction liquid slowly poured into a large amount of ice water (100L), then 50L dichloromethane extraction two times, the combined organic phase, saturated salt water washing (20L), anhydrous sodium sulfate drying, filtering, concentrating the organic phase, dried under vacuum to get yellow solid 7.2 kg, SM2 is the compound, yield 92.3%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 769-42-6, 1,3-Dimethylbarbituric acid.
Reference:
Patent; Shanghai Baiteyin Pharmaceutical Technology Co., Ltd.; Zhu Yiping; Sun Lianhua; (7 pag.)CN103755705; (2017); B;,
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