Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13036-50-5, name is 2-Chloro-4-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 13036-50-5
To a solution of compound 1-2 (1.00 g, 6.60 mmol, 1.00 eq) and 2-chloro-4-phenyl-pyrimidine (1.26 g, 6.60 mmol, 1.00 eq) in EtOH (20.00 mL) were added DIPEA(2.56g, 19.80 mmol, 3.46mL, 3.00 eq) and Na2CO3(2.10g, 19.80 mmol, 3.00 eq) at room temperature. The reaction mixture was heated to 40C and stirred for 12 h. Then the solvent was removed by rotary evaporation under reduced pressure, and the residue was diluted with water (20 mL) and then extracted with ethyl acetate. The organic phases were combined, washed with a saturated saline solution, dried over anhydrous sodium sulfate, filtered, and then concentrated. The resulting residue was separated by preparative chromatography (mobile phase: petroleum ether/ethyl acetate = 5/1) to afford compound 2-2. MS (ESI) m/z: 269.9 [M+1].
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Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; XIONG, Jian; XIE, Cheng; CHEN, Kevin X; XU, Xiongbin; ZHANG, Xuejin; GONG, Zhen; LI, Jian; CHEN, Shuhui; ZHANG, Aiming; JIANG, Zhulian; ZHANG, Xiquan; TIAN, Xin; EP3590944; (2020); A1;,
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