Analyzing the synthesis route of 13479-88-4

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13479-88-4, 5,7-Dichlorothiazolo[5,4-d]pyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13479-88-4, name is 5,7-Dichlorothiazolo[5,4-d]pyrimidine, molecular formula is C5HCl2N3S, molecular weight is 206.0525, as common compound, the synthetic route is as follows.Computed Properties of C5HCl2N3S

A 10 mL round-bottom flask, was charged withcompound 45.3 (500 mg, 2.27 mmol, 1.00 equiv) and acetic acid-d4 (5 mL). The reaction was stirred for 24 hours at 110 C. The solids were filtered out and solvents were removed under reduced pressure to provide 450 mg (89%) of intermediate 58.1 as a yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13479-88-4, 5,7-Dichlorothiazolo[5,4-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine; WO2015/48281; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia