Electric Literature of 15400-57-4, Adding some certain compound to certain chemical reactions, such as: 15400-57-4, name is Methyl 4-methoxy-2-(methylthio)pyrimidine-5-carboxylate,molecular formula is C8H10N2O3S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15400-57-4.
A mixture of of 2.2 g of methyl 4-methoxy-2-(methylthio)pyrimidine-5-carboxylate, 15 g of Raney nickel (washed with methanol to remove water) and 200 mL of methanol was stirred under 1 atm hydrogen overnight. Conversion was incomplete by LCMS so the mixture was filtered and treated with 15 g of fresh Raney nickel under hydrogen overnight. After filtration and concentration under reduced pressure, purification by flash chromatography (0%-10% ethyl acetate in hexanes) gave the prodcut as white crystalline solid: MS (m+1) = 169.1; 1H NMR (400 MHz, CDC13) 9.0 (s, IH), 8.82 (s, IH), 4.1 (s, 3H), 3.9 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15400-57-4, Methyl 4-methoxy-2-(methylthio)pyrimidine-5-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK & CO., INC.; WO2007/67511; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia