Synthetic Route of 156-81-0, Adding some certain compound to certain chemical reactions, such as: 156-81-0, name is Pyrimidine-2,4-diamine,molecular formula is C4H6N4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 156-81-0.
1 g of commercial 2,4-diamino pyrimidine was treated in 40 ml tert.-butanol with1.5 g BOC20 in the presence of 3.48 ml DIPEA at ambient temperature for 6 hrs. After evaporation, the product was extracted with ethyl acetate from water, dried with Na2S04, filtered and evaporated to dryness. After digestion with petrolether : ether 3:1 (vol) and drying 849 mg (4-amino-pyrimidin-2-yl)-carbamic acid tert-butyl ester was obtained as a white powder with Rt ~ 1.08 min and correct mass of M+H ~ 211
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Reference:
Patent; MERCK PATENT GMBH; JONCZYK, Alfred; DORSCH, Dieter; ZENKE, Frank; AMENDT, Christiane; WO2011/101069; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia