Adding a certain compound to certain chemical reactions, such as: 1780-26-3, 2-Methyl-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1780-26-3, blongs to pyrimidines compound. 1780-26-3
Example 9; 4-(l-{ [6-(2-Methoxy-phenyl)-2-methyl-pyrimidin-4-yll-hvdrazono}-ethyl)- phenyll -dimethylamine; Step-1; 4-Chloro-6-hydrazino-2-methylpyrimidine; To a solution of 4,6-dichloro-2-methylpyrimidine (1Og, 0.061 mo 1) in dry THF (500ml) was added anhydrous hydrazine (1.96g, 0.06 lmol) followed by potassium carbonate (12.7g, 0.092mol). The reaction mixture was stirred at room temperature for 13h and filtered. The filtrate was evaporated under reduced pressure to afford 9.3g (45%) of the titled compound as a solid.MP: 164-1720C, MS: Mass found (M+l, 158.9), 1H NMR (CDCl3, 300MHz): delta 2.49(3H, s), 3.05(2H, bs), 6.59(1H, bs), 6.67(1H, s).; Example 27; N-[6-(2-Fluoro-phenyl)-2-methyl-pyrimidin-4-yll-N’-[l-p-tolyl- ethylidenel -hydrazine; Step-1; 4-Chloro-6-hydrazino-2-methylpyrimidine; To a solution of 4,6-dichloro-2-methylpyrimidine (1Og, 0.061 mo 1) in dry THF (500ml) was added anhydrous hydrazine (1.96g, 0.06 lmol) followed by potassium carbonate (12.7g, 0.092mol). The reaction mixture was stirred at room temperature for 13h and filtered. The filtrate was evaporated under reduced pressure to afford 9.3g (45%) of the titled compound as a solid.LCMS: Mass found (M+l, 158.9), MP: Started melting at 1460C and decomposed at 22O0C, 1H NMR (CDCl3, 300MHz): delta 2.49(3H, s), 3.05(2H, bs), 6.59(1H, bs), 6.67(1H, s).
With the rapid development of chemical substances, we look forward to future research findings about 1780-26-3.
Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2007/65940; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia