Adding a certain compound to certain chemical reactions, such as: 183438-24-6, 5-Bromo-2-iodopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 183438-24-6, blongs to pyrimidines compound. Recommanded Product: 183438-24-6
INTERMEDIATE 163 -(5 -Bromopyrimidin-2-yl)-3 -hydroxycyclobutyl 2,2-dimethylpropanoate5-Bromo-2-iodopyrimidine (16.7 g, 58.8 mmol) was dissolved in DCM (200 mL) with stirring and cooled to -78C under N2. n-Butyllithium in hexane (2.5M, 23.5 mL)was added dropwise and the mixture was stirred for 20 minutes at -78C. Intermediate 15 (10 g, 58.8 mmol) in DCM (50 mL) was cooled in a dry ice bath and added in one portion. The reaction mixture was stirred at -78C for 10 minutes, then quenched by the addition of saturated aqueous NH4C1 solution (20 mL) and allowed to warm to room temperature. Saturated aqueous NH4C1 solution (50 mL) was added and the mixture wasextracted with DCM (2 x 100 mL). The combined organic extracts were dried over sodium sulfate and concentrated in vacuo. The crude residue was purified by column chromatography (5i02, 0-30% EtOAc in heptane), yielding the title compound (7.6 g, 35%) as a yellow solid. H (500 MHz, CDC13) 8.78 (s, 2H), 5.22-5.14 (m, 1H), 3.03-2.93 (m, 2H), 2.67-2.58 (m, 2H), 1.22 (s, 9H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,183438-24-6, its application will become more common.
Reference:
Patent; UCB BIOPHARMA SPRL; DELIGNY, Michael Louis Robert; HEER, Jag Paul; JACKSON, Victoria Elizabeth; KROEPLIEN, Boris; LECOMTE, Fabien Claude; PORTER, John Robert; WO2015/86509; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia