Analyzing the synthesis route of (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

According to the analysis of related databases, 1197953-49-3, the application of this compound in the production field has become more and more popular.

Electric Literature of 1197953-49-3, Adding some certain compound to certain chemical reactions, such as: 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide,molecular formula is C12H12Cl2N3OP, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1197953-49-3.

The above compound B (0.1g, 0.53mmol) and 4-(ortho dimethyl phosphinyl anilino)- 5- chloro – 2-chloro pyrimidine (0.17g, 0.53mmol) were dissolved in a mixture of 2-butanol (1.2mL) & trifluoroacetic acid (0.25 mL) and were heated to 100 C in a seal tube for overnight. The reaction mixture was then cooled to rt and poured into a saturated NaHCC solution while stirring to afford an orange solid which was filtered, washed with Et.20 to remove final traces of water. The product was dried to afford C (0.19g) which was directly used in the next step.

According to the analysis of related databases, 1197953-49-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; ZHU, Xiaotian; WANG, Yihan; SHAKESPEARE, William, C.; HUANG, Wei-Sheng; DALGARNO, David, C.; WO2013/169401; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia