Synthetic Route of 3993-78-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3993-78-0, name is 2-Amino-4-chloropyrimidine, molecular formula is C4H4ClN3, molecular weight is 129.55, as common compound, the synthetic route is as follows.
A mixture of 2-amino-4-chloro-pyrimidine (7,5 mmol, 1g) with DMAP (0,2 eq, 1,5 mmol, 183,5 mg), triethylamine (0,2 eq, 1,5 mmol, 0,2 ml) and di-tert-butyl-dicarbonate (2 eq, 15 mmol, 3,2 g) in dichloromethane (60 mL) was stirred at room temperature for 48 h. When the reaction was finished the solvent is evaporated and the resulting crude was dissolved in CH2Cl2 and washed with water. The organic phase was evaporated to dryness in vacuo and the residue purified by silica gel column chromatography using as eluent AcOEt/Heptane in gradient. NMR (CDCl3): delta ppm 7.9 (d, 1H); 6.52 (d, 1H); 1.43 (s, 18 H)
The chemical industry reduces the impact on the environment during synthesis 3993-78-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; NOSCIRA, S.A.; Medina Padilla, Miguel; Dominguez Correa, Juan Manuel; Fuertes Huerta, Ana; Palomo Nicolau, Francisco; Lopez Ogalla, Javier; Herrero Santos, Susana; Alonso Cascon, Mercedes; Alonso Gordillo, Diana; Rubio Arrieta, Laura; EP2647634; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia