Electric Literature of 13036-57-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13036-57-2, name is 2-Chloro-4-methylpyrimidine, molecular formula is C5H5ClN2, molecular weight is 128.56, as common compound, the synthetic route is as follows.
A solution of Lithium bis(trimethylsilyl)amide (1M in THF, 10.26mL, 10.26mmol) was added to a cooled (0C) solution of Methyl 3-((tert-butoxycarbonyl)amino)-2- fluorobenzoate (790mg, 2.93mmol) in THF (15mL). After lOmin of stirring, a solution of 2-chloro-4-methylpyrimidine (452mg, 3.52mmol) in THF (2mL) was slowly added and the reaction mixture was allowed to warm to 40C for lh. Aqueous saturated ammonium chloride was added to the medium. The aqueous layer was extracted with EtOAc (2 times). Combined organics were washed with brine, dried over sodium sulphate, filtered and the filtrate was concentrated under reduced pressure. Purification of the residue by flash chromatography on silica gel (cHex-EtOAc 1/0 to 0/1) afforded the title compound (880mg, 82%). LC/MS (ES+): 366.3-368.3 (M+l).
Statistics shows that 13036-57-2 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4-methylpyrimidine.
Reference:
Patent; CELLIPSE; PRUDENT, Renaud; PAUBLANT, Fabrice; (74 pag.)WO2018/55097; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia