Reference of 33034-67-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine, molecular formula is C5H2ClF3N2, molecular weight is 182.531, as common compound, the synthetic route is as follows.
Step 7: To a solution of l-isopropyl-7-(methylthio)-l,2,3,4-tetrahydropyrazino[l,2-a]indole (50 mg, 0.19 mmol) in ‘PrOH (2 mL) was added 2-chloro-4-(trifluoromethyl)pyrimidine (105 mg, 0.58 mmol) and DIEA (185 mg, 0.96 mmol). The mixture was stirred at 100 °C for 4 h. The mixture was concentrated under vacuum and the residue was purified by preparative TLC to afford l-isopropyl-7-(methylthio)-2-(4-(trifluoromethyl)pyrimidin-2-yl)-l,2,3,4- tetrahydropyrazino[l,2-a]indole (45 mg, 57.7percent yield) as a yellow oil.LC-MS MS (ESI) m/z 407.1 [M + H]+.
Statistics shows that 33034-67-2 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4-(trifluoromethyl)pyrimidine.
Reference:
Patent; VITAE PHARMACEUTICALS, INC.; DONG, Chengguo; FAN, Yi; LEFTHERIS, Katerina; LOTESTA, Stephen; SINGH, Suresh, B.; TICE, Colin; ZHAO, Wei; ZHENG, Yajun; ZHUANG, Linghang; WO2013/138565; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
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