Analyzing the synthesis route of 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,335654-06-3, its application will become more common.

Reference of 335654-06-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 335654-06-3 as follows.

2-chloro-7H-pyrrolo[2,3-T]pyrimidine (330 mg; 2.15 mmol) and JV-iodosuccinimide (580 mg; 2.58 mmol) are taken up in 3.3 mL DMF and stirred for 1 h at 200C. The reaction mixture is extracted with sodium thiosulphate solution and ethyl acetate. The combined organic phases are dried, the solvent is eliminated in vacuo and A.21 (EtaPLC- MS: tRet. = 1.60 min; MS(M+Eta)+ = 280; method FEC3) is obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,335654-06-3, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; BOEHMELT, Guido; KOFINK, Christiane; KUHN, Daniel; MCCONNELL, Darryl; STADTMUELLER, Heinz; WO2010/7116; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia