Analyzing the synthesis route of 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,890094-38-9, its application will become more common.

Electric Literature of 890094-38-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 890094-38-9 as follows.

N-(3-aminophenyl)acrylamide(3.2g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 3 hours, cooled to room temperature, filtered, washed and dried to obtain a red solid(6.0g) in a yield of 88.3%. MS m/z(ESI): 344[M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,890094-38-9, its application will become more common.

Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia