Reference of 75833-38-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.75833-38-4, name is 2-Chloropyrimidine-4-carbonitrile, molecular formula is C5H2ClN3, molecular weight is 139.54, as common compound, the synthetic route is as follows.
1.2 (2-Chloro-pyrimidin-4-ylmethyl)carbamic acid tert-butylester; 2-Chloropyrimidine-4-carbonitrile (24 g), 40.8 g of t-butyl dicarbonate (BOC2O) in 1.2 L of methanol and 5 g of Raney nickel (Raney 2400) were charged in an autoclave. The autoclave was sealed and purged with hydrogen. The hydrogenation was run at 30 psi hydrogen gas. The reduction was carried out to completion and the reactor was vented and purged with nitrogen. The reaction mixture was filtered over diatomaceous earth and the filtrate was concentrated. The residue was purified by chromatography to yield the title compound (35 g, 84%) as white solid of melting point of 86-88 0C.
Statistics shows that 75833-38-4 is playing an increasingly important role. we look forward to future research findings about 2-Chloropyrimidine-4-carbonitrile.
Reference:
Patent; BASF SE; WO2008/62011; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia