Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 14631-08-4, name is 2-Chloropyrimidine-4,5-diamine. A new synthetic method of this compound is introduced below., Safety of 2-Chloropyrimidine-4,5-diamine
Intermediate 82: Mixture /V-(5-amino-2-chloro-4-pyrimidinyl)-2-oxo-3-phenyl-1-oxa-3- azaspiro[4.51decane-8-carboxamide and lambda/-(4-amino-2-chloro-5-pyrimidinyl)-2-oxo-3- phenyl-1-oxa-3-azaspiro[4.51decane-8-carboxamide; (Trans^-oxo-S-phenyl-i-oxa-S-azaspiro^.deltaJdecane-delta-carboxylic acid (Intermediate 10 alternative preparation, 239 mg, 0.286 mmol), 2-chloro-4,5-pyrimidinediamine (commercially available, 41.4 mg, 0.286 mmol) and EDC HCI (88 mg, 0.458 mmol) were dissolved in pyridine (2 ml) and stirred at room temperature overnight. The solvent was removed under vacuum to give a residue which was purified by silica gel chromatography (5g cartridge) eluting in gradient with CyclohexaneEtOAc 9:1 to 1 :1 then DCMMeOH 95:5 to afford the title compound as a pale yellow solid (35 mg, 30%), mixture of regio and stereoisomers with unknown ratio). UPLC-MS: 0.60 min, m/z 402 [M+H]+.
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Reference:
Patent; GLAXO GROUP LIMITED; WO2008/129007; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia