Adding a certain compound to certain chemical reactions, such as: 1780-26-3, 2-Methyl-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1780-26-3, blongs to pyrimidines compound. name: 2-Methyl-4,6-dichloropyrimidine
To stirred solution of 13M sulfuric acid (125 mL) at about 0 C., 4,6-dichloro-2-methylpyrimidine (20.0 g, 307 mmol) was added portion wise over about 30 min. The solution was then stirred at about 0 C. for about 1.5 h and the reaction was allowed to warm to ambient temperature over about 1.5 h. The reaction was allowed to stir at RT overnight. The acidic mixture was poured into stirred 6N sodium hydroxide (500 mL) in ice, maintaining the temperature white solid was collected and washed with warm water to afford 6-chloro-2-methylpyrimidin-4-ol 40.2 g (91%) 1H NMR (400 MHz, DMSO) delta: 12.85 (brs, 1H), 6.34 (s, 1H), 2.30 (s, 3H). LC/MS (Table 1, Method d) Rt=0.74 min; MS m/z: 145.1 (M+H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1780-26-3, its application will become more common.
Reference:
Patent; Abbott Laboratories; Calderwood, David J.; Breinlinger, Eric C.; Swann, Steven L.; Chitty, Venkata Srikanth; Shastry Hosahalli, Subramanyah Seetharama; Mukherjee, Subhendu; Thunuguntla, Siva Sanjeeva Rao; US2013/23526; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
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