Analyzing the synthesis route of 2,4-Dichloro-5-ethoxypyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,280582-25-4, 2,4-Dichloro-5-ethoxypyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.280582-25-4, name is 2,4-Dichloro-5-ethoxypyrimidine, molecular formula is C6H6Cl2N2O, molecular weight is 193.0306, as common compound, the synthetic route is as follows.Recommanded Product: 2,4-Dichloro-5-ethoxypyrimidine

-(2-Chloro-5-ethoxy- yrimidin-4-yl)-mo holine [0096] 2,4-dichloro-5-ethoxy-pyrimidin (2.83 g, 1.0 eq) was stirred in toluene(20 ml) and a solution of morpholine (1.93 ml, 1.5 eq) in toluene (20 ml) was added dropwise at -10~0C. After stirring the resulting solution overnight at r.t, NH4Cl(aq) was added to the solution and the solution was extracted with EA. The combined organic layers were washed with brine, dried and evaporated in vacuo. A product was obtained as a white solid (2.7 g , 73.5%).1H NMR (500 MHz, CDCl3-di): 61.41-1.44(m, 3H), 3.75-3.77(m, 4H), 3.83-3.85(m, 4H), 4.01-4.05(m, 2H), 7.69(s, 1H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,280582-25-4, 2,4-Dichloro-5-ethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; DEVELOPMENT CENTER FOR BIOTECHNOLOGY; DCB-USA LLC; KUO, Mann-Yan; LEE, Ying-Shuan; CHEN, Paonien; CHEN, Li Jung; LU, Yann Yu; HUANG, Yi-Ting; HSU, Hung-Yi; TSAI, Ping-Kuei; WO2011/80568; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia